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Description
In practice, the GLP-1 and GIP components counteract this effect

J Diabetes Complications 2023;37:108632

Perception, approach and management of loss of appetite: a cross-sectional, questionnaire based physician survey
Unlike traditional fillers, they dont fill space instantly

In contrast, during the withdrawal phase, GLP-1RAs appear to exert effects through broader circuits involving the lateral septum, hypothalamus, and brainstem nuclei, modulating stress responsivity, negative affect, and somatic symptoms, as evidenced in models of opioid and nicotine withdrawal
doi: 10.21037/atm-22-6366