glp-1 agonist examples receptor agonists GLP-1 Agonists For Obesity In

Obesity While at the most basic level, obesity is caused by a person taking in more energy than they expend over a prolonged period, it is worth noting that humans have a complex neural mechanism regulating food intake, which is generally very effective at maintaining a balance between energy intake and expenditure

For example, a medication might strongly activate brain GLP-1 receptors for appetite suppression while only partially activating gut receptors that contribute to nausea

Additionally, some individuals may experience side effects, such as nausea or digestive issues, which often require adjusting the dosage under medical supervision

Baggio LL, Drucker DJ

Current drug safety

Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions