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Whether this should be regarded as specific metabolic treatment, targeting only the metabolic alterations of the syndrome, is debatable, since the improvement in metabolic conditions, e.g., insulin resistance, would tenably have a positive impact also in gonadal function in women with PCOS

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Finally, a rare but serious side effect of GLP-1 receptor agonists is a potential risk for thyroid cancer

doi: 10.1016/j.jacbts.2018.09.004

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In the low-glucose (0.1 mM) state, DCA-stimulated GLP-1 secretion was completely inhibited by 1-M pasireotide treatment, paralleling the cAMP levels in GLUTag cells (Fig