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Enzymes and stomach acids break down proteins quickly, meaning only a tiny fraction of an oral dose is successfully absorbed into systemic circulation

Without adequate protein intake and resistance training, a significant share of the weight lost on a GLP-1 will be lean mass rather than fat particularly concerning for older adults where sarcopenia is already a risk

Thus, the cardioprotective action of GLP-1 receptor stimulation may occur through a number of pathways encompassing effects on metabolism, contractility and apoptosis

C., Thomson, J

The effects of semaglutide on kidney oxygenation, albuminuria and eGFR will be assessed in people with type 1 diabetes as part of the REMODEL-T1D mechanistic trial (NCT05822609)
