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For years, the GRAS loophole let companies declare ingredients safe without FDA oversight

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CrossRef Efficacy and safety of pioglitazone, empagliflozin and glimepiride as thirdline agents in patients with type 2 diabetes inadequately controlled with metformin and DPP4 inhibitors: A multicentre, phase 4 randomized controlled trial Yun Kyung Cho, JaeHyoung Cho, SangMo Hong, Jung Hwan Park, ByungWan Lee, Jee Hee Yoo, Jae Hyeon Kim, Sung Wan Chun, YouCheol Hwang, KeeHo Song, Woo Je Lee Diabetes, Obesity and Metabolism.2025

We can expect to see the results of several new studies looking at CagriSemas effectiveness and tolerability in the next year to see if this holds true