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This means that if you do not respond well to GIP receptor activation (which tirzepatide relies on), CagriSema amylin pathway may work where tirzepatide did not

Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) are currently underway and will provide the definitive comparison data

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Figure 26: Photograph of Professor Jens Holst with Dr Karen Thorne, a member of his laboratory, carrying out an experiment with a perfused pig pancreas in the 1990s, credit: Holst

15,23 This issue has been addressed by the synthesis of small molecule GLP-1RA that have smaller molecular sizes and can be administered orally offering a more convenient and acceptable option to patients