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In high-risk populations, GLP1RAs also reduce the risk of major adverse cardiovascular events, including all stroke and non-fatal stroke

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Oral semaglutide is the only orally administered GLP-1 receptor agonist currently available and has been associated with reductions in glycated hemoglobin and body weight versus once-daily injectable liraglutide after 52 weeks in the PIONEER 4 clinical trial

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Here, we report the identification of a tripeptide with significant potential to treat T2D

GLP-1 medications may increase kidney stone risk through dehydration and uric acid changes, but individual risk depends on baseline kidney function, hydration status, and metabolic factors