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Another potential issue is that beneficiaries who participate in the short-term program will need to be enrolled in a Part D plan that participates in the longer-term demonstration, called the BALANCE Model, to continue accessing Medicare coverage of GLP-1s for obesity starting in 2027

Furthermore, prescription medications in this class carry an FDA warning regarding thyroid tumors based on animal studies

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& Defronzo, R

Therefore, between-study heterogeneity may limit our ability to determine the degree to which GLP-1 RAs affect glutamatergic signaling across disparate brain regions and how the trends would extrapolate to human populations