glp-1 receptor agonist medications list drug names GLP-1 Agonist List: Find out how each one works GLP-1 receptor agonist Drug list

Key Points Native human GLP-1 normalizes hyperglycaemia in patients with type 2 diabetes mellitus, but the short in vivo half-life of this hormone limits its therapeutic application A number of synthetic GLP-1 receptor agonists, with half-lives between 23 h and several days, have been developed for the long-term treatment of type 2 diabetes mellitus Short-acting GLP-1 receptor agonists (such as exenatide and lixisenatide) predominantly lower postprandial glucose levels and insulin concentrations via retardation of gastric emptying Long-acting GLP-1 receptor agonists (such as albiglutide, dulaglutide, exenatide long-acting release and liraglutide) predominantly lower blood glucose levels through stimulation of insulin secretion and reduction of glucagon levels Adverse effects of GLP-1 receptor agonists include nausea, vomiting and diarrhoea, injection-site reactions, antibody formation and increased heart rate This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 186,36 per year only 15,53 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

It helps regulate blood sugar, slows stomach emptying, and makes you feel full for longer

Patients can choose a convenient time for the injection, but it should be administered at the same time each day

Others adjust the pH of the solution to optimize the balance between compound stability and mucosal permeability

doi: 10.1038/nrendo.2012.140 4 DruckerDJHabenerJFHolstJJ

That statement may change as research evolves, but it is the honest statement today