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To attain these health benefits, however, it is critical that people prescribed GLP-1s continue to take them at least long enough to realize clinical success, and preferably longer to avoid possible weight rebound once they come off the medications

Never attempt to remove the cartridge or disassemble the pen yourself, as this compromises sterility and device function
Research shows that people who combine GLP-1s with healthy eating have more long-term success with weight loss and fewer complications and side effects

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doi: 10.1016/j.clnu.2022.10.001
Without titration, the sudden introduction of 8 mg or 12 mg would likely have produced far more intolerances and early withdrawals, compromising the validity of the results
