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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

One way clinicians sometimes think about dose adjustments is through a simple sequencing model: Stabilize Calibrate Accelerate Preserve This model is a conceptual way to describe how physiological factors can influence dosing decisions

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For driven professionals, stable blood sugar translates directly to more consistent energy, sharper focus, and less brain fog

For individuals who meet the criteria for GLP-1 medications for weight loss, drugs such as Wegovy (Semaglutide) and Zebound (Tirzepatide) are FDA-approved treatment options