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The HR for the expanded MACE outcome was similar to that of the primary outcome (HR 0.82

Clinical trials show average weight loss of 5-10% of body weight over 56 weeks with liraglutide 3.0 mg daily, compared to tirzepatide at 20-22%

The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells (49, 50), underlining the numerous roles for GLP-1-signaling beyond blood glucose control

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Based on the earlier discussed receptor expression, innervation and their crucial role in behavioral control two mesolimbic nuclei, the VTA and the NAc, became the first targets of studies exploring behavioral consequences of the mesolimbic GLP-1R activation