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The difficulty of maintaining adherence to weekly injections can lead to treatment fatigue and weight regain, frustrating both patients and providers

Still, side effects can make it tough to stay the course, particularly if they punch hard up front

doi: 10.1001/jamasurg.2016.2317 5 Sanchez-GarridoMABrandtSJClemmensenCMullerTDDiMarchiRDTschopMH

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Dailey MJ, Moran TH

However, it's important to note that many of these studies are observational and do not prove that GLP-1 medications cause the reduced risk

Other serious side effects include increased blood pressure and heart rate and, less commonly, liver damage or hepatitis, vision problems, increased risk of low blood sugar in people with type 2 diabetes, or manic episodes