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Like GLP-1, GIP helps regulate insulin and reduce appetite, but it also boosts fat metabolism and improves insulin sensitivity

Mechanistically, SSRI interactions with cardiac sodium (Na) and hERG potassium channels alter repolarization dynamics, producing QTc prolongation and conduction delays under susceptible conditions

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Reference lists of relevant published reviews and clinical guidelines were also manually screened to capture additional real-world comparative cohorts

The GABA C selective agonist, CACA (0.1 mm), also stimulated GLP-1 release, but was less effective than GABA