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In biochemical and preclinical research systems, GLP-RT interacts with three class B G protein-coupled receptors that regulate metabolic signaling networks: GLP-1R, GIPR, and GCGR

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While peptide drugs have a wide range of therapeutic applications, their relatively short half-life has been a challenge, attributed to poor metabolic stability and a fluid dynamic radius below the glomerular filtration limit of the kidneys.

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