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Specific variants in GLP1R and GIPR genes may predict differential sensitivity to semaglutide or tirzepatide, a consideration that becomes even more relevant after anatomical surgery

The most important results from the clinical studies involving danuglipron are shown in Table 1

Avoid high-fat and high-fiber foods immediately after injection, as these slow digestion further and compound the drug's natural effect on gastric motility

injection site reactions in injectable formulations can produce localized itching or irritation

Temporary storage outside the refrigerator: If needed, unopened tirzepatide pens may be stored at temperatures up to 30C for up to 21 days before use

Ken Fujioka, MD, can be reached at [email protected]