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Parallel-import fast tracks eased but did not fully resolve supply gaps, and broader IMSS formulary inclusion remains the swing factor for future growth

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.St-Onge M.P., Tasali E

A major challenge was that native GLP-1 is rapidly degradedwithin about two minutesby the enzyme dipeptidyl peptidase-4 (DPP-4)

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As weak agonists tend to become partial agonists when receptor density is limited 32 , this may indicate failure of the slowly internalizing compounds to maximally exploit the residual surface receptors