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Patients with type 2 diabetes and early-to-moderate kidney disease (stages 13) typically experience the strongest kidney-protective effects from semaglutide

doi: 10.1530/EJE-14-0309

It delivers a gentler dose profile, ideal for patients new to GLP-1 therapy or those exploring tolerance before advancing to standard-dose protocols

Given that this disorder represents a model of extreme modification of glucose metabolism in response to bariatric/metabolic surgery, understanding the metabolic pathways perturbed in PBH may inform our understanding of intestinal regulation of glucose homeostasis and uncover new therapeutic targets for PBH and, more broadly, for nonsurgical approaches to improve systemic glucose metabolism