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This mechanism enhances insulin secretion in response to meals, suppresses glucagon release, slows gastric emptying, and reduces appetitecollectively helping to improve glycaemic control and promote weight loss

Birth of the incretin concept The same year Lim and Kosaka published their hypothesis, the Belgian physiologist La Barre attempted to purify secretin with Eugene Still, a colleague at the University of Chicago

Weeks 5 through 8: Reduce to 10 mg weekly

This lack of FDA approval means they haven't undergone the rigorous testing for safety, efficacy, and quality that regulated medications do

Reduced joint pain from estrogen means more ability to exercise

Step therapy is common