glp-1 receptor agonists alternatives to ozempic FDA approves Foundayo, an oral alternative Wegovy and Five Unexpected New Uses for

The GLP-1 receptor is a type of cell surface receptor that binds to GLP-1, triggering a signaling cascade that leads to various effects, including the stimulation of insulin secretion, the inhibition of gastric emptying, and the promotion of satiety

Sodium-glucose cotransport protein 2 inhibitors in patients with type 2 diabetes and acute kidney disease

CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

Additionally, the findings may have limited generalizability because the Mass General Brigham population is older, less likely to have a BMI of 25 or higher, less representative of Black and Latino individuals, and less likely to have public insurance

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GLP-1RAs also exert anti-arrhythmic effects via reducing calcium leak from the sarcoplasmic reticulum in ventricular arrhythmia, which has the potential to decrease phosphorylation of the type 2 ryanodine receptor (RyR2) and alleviate the activity of CaMK-II [77]