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Position emission tompraphy (PET) scans using [18F]-FDG were performed during a hyperinsulinemic-euglycemic clamp (HEC) to measure regional FDG uptake before and after the four- week treatment with SGLT-2i

doi: 10.1073/pnas.2012196117 [DOI] [PMC free article] [PubMed] [Google Scholar] 59

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Exercise helps to burn calories, regulates energy expenditure and helps maintain weight loss once achieved

This suggests that Ozempic itself doesnt directly cause headaches

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha