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Combination Therapy: Often used alongside other hypoglycemic agents for enhanced efficacy

Zierer, J

Hypoglycemia The use of pramlintide with insulin has been associated with an increased risk of insulin-induced severe hypoglycemia in both T1D and T2D

SIRT1 can deacetylate LKB1, an upstream regulator of AMPK, increasing the cytoplasmic localization of LKB1 and thus promoting AMPK activation

Controlling hyperglycemia and preventing the chronic complications of diabetes have long been recognized as the main goals of diabetes management

In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials