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Consequently, IGFBPs regulate diverse cellular processes such as proliferation, adhesion, migration, survival, growth, apoptosis, senescence, autophagy, and angiogenesis through IGF-dependent and IGF-independent pathways [93, 101, 103]
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Similar results were reported in mice treated with GLP-1/dexamethasone, an unimolecular peptide-nuclear hormone conjugate designed to optimize dexamethasone delivery into GLP-1R positive cells [820]
Tesamorelin is FDA-approved for adult visceral fat reduction in HIV-associated lipodystrophy
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