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Childhood obesity rates have skyrocketed over 300% since the 1970s, now affecting 21% of children

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Do not use it if the safety seal is broken or missing

GLP-1 RAs have been linked to bowel obstruction, particularly in those with prior GI motility problems

Recent findings indicate that GLP-1 hormone might be particularly important for gut microbiota's role in the feeling of satiety.

Therefore, although DPP-4 inhibitors have attractive clinical features, the benefits that might be expected from GLP-1 signaling may be undermined by their actions to enhance SDF-1.