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La agencia habla por tanto de problemas potenciales de seguridad

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(2) Estimate the absolute change in HbA1c, estimated glomerular filtration rate (eGFR), and cholesterol levels during 1year treatment with GLP1 RA compared with treatment with metformin, in subgroups by whether the patient had prediabetes or diabetes to evaluate realworld use

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A limitation of this study is that the weight loss in the RETA group could not be matched simply by restricting food intake due to the many pathways targeted by RETA leading to, for example, significantly elevated cecal content indicative of reduced gastric motility