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[DOI] [PMC free article] [PubMed] [Google Scholar] 294.Kleinert M., et al

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However, in a co-agonist molecule, glucagon receptor activation occurs alongside GLP-1 and, in the case of retatrutide, GIP receptor activation

Because they influence how your body processes energy and manages key functions, they can also affect electrolyte balance.Why GLP-1 users need to pay attention to electrolytesBecause of the effects GLP-1 RAs have on digestion and appetite signals, GLP-1 users may eat less, drink less, and absorb less, explains Kwadwo Kyeremanteng, MD, department head of critical care at The Ottawa Hospital and LMNT Partner.Together, this increases the risk of dehydration and electrolyte imbalances even in people who dont feel sick, he adds.Some people might also experience medication side effects, such as vomiting or diarrhea, which could contribute to further alterations in hydration and electrolyte balance.Why does electrolyte balance matter in the first place