allodynia glp-1 is being reported with medications It is a heightened sensitivity to touch that can feel like pain. We are seeing it more at higher doses The important point is that Glucagon-like Peptide-1 Receptor Agonists as
Description
On the negative side of things, the FDA updated the label for Ozempic with a warning about intestinal blockages after multiple reports of the rare but severe side effect

Sun Y., Liu Y., Dian Y., Zeng F., Deng G., and Lei S., Association of GlucagonLike Peptide1 Receptor Agonists With Risk of CancersEvidence From a Drug Target Mendelian Randomization and Clinical Trials, International Journal of Surgery 110 (2024): 46884694
Abstract Background: Pancreatogenic Diabetes Mellitus (PDM), denoting diabetes secondary to fibro-inflammatory and structural pancreatic injury, represents a distinct yet under-recognised clinical entity

The data were expressed as fold-over basal insulin secretion (ng insulin/g protein)

Increasing your intake of water and soluble fiber is the first step in managing constipation
First, context matters enormously