glp-1 agonists in development History of glucagon-like peptide-1 receptor GLP-1 Receptor Agonists in Solid

This was interesting because at that time it was assumed that the best way to treat patients with metabolic disorders was not to stimulate more glucagon because it raises blood sugar, but instead to block it

Regul Pept 2010

STEP 1 for Effective Weight Control Another First Step

J Endocrinol Invest 2023

161,167 Small molecule GLP-1RAs Currently, most GLP-1RAs are based on proteins or peptides, meaning they are large molecules typically administered via injection

These alternatives work through different mechanisms than prescription semaglutide and typically produce more modest effects on blood glucose control and weight management