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Those trends cut against the super-sized model that has long underpinned fast-food profitability, where customers barely paused before "supersizing" fries for under a dollar or choosing a burger with an extra patty

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semaglutide market grew by over 300% between 2021 and 2023, reflecting both clinical demand and broader awareness of GLP-1 receptor agonists

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Metformin can contribute to gastrointestinal upset as well, so patients beginning this combination may need a gradual titration of semaglutide doses to allow tolerance to develop