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The exception is the first 24-48 hours after a dose escalation, when peak concentration is highest

This enhanced metabolic flexibility could contribute to the sustained weight loss and glycemic improvements observed with tirzepatide therapy

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It will be interesting to see whether the new and effective therapeutic alternatives under development for obesity enable a more effective decrease in body weight, which, in turn, could be beneficial for the outcome of immune-mediated dermatoses

Additional considerations include the impact on weight management goals

Patients without coverage face $1,000+ monthly costs that make sustained treatment financially challenging