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In healthy subjects, oral glucose triggers a stronger insulin secretion response than intravenous glucose because of the secretion of incretin from the gastrointestinal tract, known as the incretin effect. Clinically, incretin-based drugs include glucagon-like peptide 1 receptor agonists (GLP-1 RA) (such as liraglutide) and dipeptidyl peptidase 4 inhibitors (DPP-4i) (such as vildagliptin)

Its basic physiology, but it doesnt always register in the moment

TRANSCEND-T2D-1 (NCT06354660) will compare the efficacy and safety of retatrutide compared to placebo in people with inadequately controlled T2D treated with diet and exercise over a period of 11 months

doi: 10.1016/0306-4530(94)90017-5

Furthermore, recent regulatory changes in insurance coverage have added another layer of complexity

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