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Medical Safety Considerations When Combining These Therapies Starting Zepbound while already taking testosterone requires a clear medical history review and baseline laboratory assessment

The active ingredients, semaglutide and tirzepatide, are FDA-approved in commercial formulations such as Wegovy, Ozempic, Mounjaro, and Zepbound

However, stacking these treatments without medical guidance can increase risks of gastrointestinal side effects, blood sugar fluctuations, and unexpected drug-supplement interactions

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But if the same medication also receives FDA approval to reduce the risk of heart attacks, strokes and other major adverse cardiovascular events, it could be added to Part D formularies for people with established heart disease, the agency said

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