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Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Published 2025 Apr 14

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Protein shakes designed for GLP-1 users help maintain muscle mass during rapid weight loss

Mechanistically, GLP-1 enhances insulin secretion in response to food intake, inhibits glucagon release, and slows gastric emptying, contributing to its therapeutic role in reducing blood glucose levels and body weight [21]