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Well, the first study comparing modern drugs to surgeries that weve been doing for decades is out, and as you guessed it, bariatric surgery win
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The phase 2 and phase 3 clinical trials used the same starting dose for all weight groups

GLP-1(32-36)amide pentapeptide increases basal energy expenditure and inhibits weight gain in obese mice

A metanalysis by Bray et al
CREB-dependent transcription, possibly altering the synthesis of secretory proteins or ion transporters that regulate saliva composition
