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Some early studies suggest that GLP-1 medications may contribute to skin thinning or disrupt signaling pathways involved in cell turnover, collagen formation, and elastin production

While the benefits of semaglutide in treating obesity and type 2 diabetes are well-established, it is important to consider the effects that may occur when treatment is discontinued

The number of reported serious side effects was 5.65% with semaglutide 0.5 mg, 7.67% with semaglutide 1.0 mg, 8.03% with dulaglutide 0.75 mg and 7.36% with dulaglutide 1.5 mg

Younossi ZM, Mangla KK, Chandramouli AS, et al

While semaglutide can be highly effective, like any medication, it comes with possible side effects some mild, some more serious

By contrast, tirzepatide (GIP/GLP-1 RA) has not shown a similar risk signal in the SURPASS trials despite achieving even greater glycemic and weight benefits