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Regina DePietro, MD, a family medicine physician at MU Health Care in Columbia, Missouri, says that people also may microdose GLP-1s if they only want to lose a small amount of weight

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An analysis published this week in JAMA Internal Medicine found that most participants in a clinical trial who were assigned to stop taking tirzepatide (Zepbound from Eli Lilly) not only regained significant amounts of the weight they had lost on the drug, but they also saw their cardiovascular and metabolic improvements slip away

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If you see a small drop of blood or medication at the site, press gently with a clean cotton ball or gauze

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I focused on habits that worked long-term, not quick fixes

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They do not prevent it

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Below is detailed analysis of key trials: STEP 1: Primary Efficacy Trial Citation : Wilding JPH, et al

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