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Additionally, studies employing cortical pattern matching have shown diminished cortical gray matter thickness in the left anterior cingulate cortex among individuals with T2DM, with those co-diagnosed with major depression exhibiting significant cortical gray matter reductions in bilateral prefrontal areas when compared to healthy controls [102]

Further RCTs are needed to fully explore the therapeutic potential of GLP-1 agonists and GIP/GLP-1 combination drugs for the treatment of Alcohol Use Disorder

While both offer distinct pathways to supporting metabolic health, the prospect of combining them raises crucial questions regarding efficacy, safety, and potential interactions

Finally, while our projections were based on SOUL trial effect sizes, real-world differences in adherence, comorbidities, and access to care may limit generalisability

The injectable is usually taken once weekly, while the tablets are taken once daily

Further increases in 2.5-mg increments should take place at 4-weekly intervals if higher doses are needed