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While its associations with cardiovascular, hepatic, and metabolic disorders are well established, the impact of obesity on the pancreas has received comparatively less attention

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For adults with obesity (BMI 30 kg/m or 27 kg/m with comorbidities) and no contraindications, retatrutide should be initiated at 2 mg subcutaneously once...

Although the higher dose showed modest within-group weight reduction and improved HbA1c, unexpectedly substantial placebo-associated weight loss limited the observed treatment effect.