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The existing drugs already work well enough that off-label use is happening

The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]

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Powell-Wiley TM, Poirier CP, Burke VCLE, Desprs JP, Gordon-Larsen P, Lavie CJ, et al

Many patients transition in the Mounjaro vs Trulicity decision after trying one medication first

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