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As such, GLP-1 is present in circulation at low levels in fasting humans and begins to increase in the first few minutes after nutrient ingestion, peaking ~6090 min postprandially at ~15 pmol/L of active GLP-1 97,100

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doi: 10.1042/bj1700615

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Yet, the GLP-1R is also expressed in the heart and vasculature, suggesting that GLP-1R agonism may impact the cardiovascular system
