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The phase 3 SELECT trial highlighted semaglutide 2.4 mgs capability to cut the risk of major adverse cardiovascular events by 20% in individuals with obesity compared to a placebo, leading to an updated label for Wegovy

That said, Wegovy is FDA-approved and widely prescribed for weight loss with excellent clinical responses, while retatrutide is still an investigational drug only available through clinical trials and its long-term safety and tolerability are still being studied

Compared with insulin monotherapy, liraglutide combined with insulin significantly reduced MCP-1 and nuclear factor-B (NF-B) levels in T2DM patients [157]

Sticking to the same exact spot or not changing sites might cause scar tissue that can slow or change the drugs effects
