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Saxenda contains the active ingredient liraglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist

Notwithstanding, previous studies have documented beneficial effects of the activation of estrogen receptors in diet-induced obese females, by reducing body weight and fat accumulation and improving leptin resistance at central level 53,54

48 Similarly, among obese individuals without diabetes, semaglutide use was shown to increase the risk of developing GI adverse events by 1.59 times compared with the control group

The three potentially blinding eye conditions included NAION, papillitis, and paracentral acute middle maculopathy

Vomiting occurs in 5-10% of patients, more commonly with Ozempic

Search terms included a combination of Medical Subject Headings (MeSH) and free-text terms, such as GLP-1 receptor agonist, semaglutide, liraglutide, dulaglutide, cardiovascular outcomes and major adverse cardiovascular events