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N Engl J Med (2014) 370(9):7947.10.1056/NEJMp1314078 66 LovshinJAZinmanB

Romero-Gomez M, Armstrong MJ, Funuyet-Salas J, Mangla KK, Ladelund S, Sejling AS, et al

Further dose increases of 2.5 mg can be considered at intervals of at least 4 weeks, up to a maximum of 15 mg weekly, based on individual response and tolerability

, & Merchenthaler, I

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However, the same Authors in the second study, failed to demonstrate a reduction in HOMA-IR, fasting glucose and insulin and glucose and insulin during OGTT in both treated groups [58]