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Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease

Finally, in 2017, a drug called Ozempic arrived, approved by the FDA to treat type 2 diabetes

10.1210/jcem.76.4.8473405 4

This was supported by a recent metanalysis in which, twenty- two randomized controlled trials involving 61,412 patients who were either T2DM patients with or without cardiovascular disease or patients with cardiovascular disease alone, were included in the meta-analysis, and results have shown the diastolic function according to echocardiography was significantly improved by GLP-1R agonists [88]

Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1

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