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Clinical evidence supports careful, provider-guided laxative use alongside dietary and lifestyle modifications for managing GI comfort during GLP-1 therapy

Replace Potassium A) Oral Potassium Replacement (Preferred) Used for mild to moderate hypokalemia Safer than IV Give with food to reduce GI irritation Slow and steady correction Good for: Stable patients Ability to take orally Gradual potassium decline B) Intravenous (IV) Potassium Replacement Use only when: Severe hypokalemia Symptomatic (arrhythmias, paralysis) Cannot take oral therapy Ongoing significant potassium losses Safety points (VERY IMPORTANT): IV potassium must be given slowly Must be diluted properly Cardiac monitoring required for rapid or higher doses Never give as IV push 4

Conclusions Hypomorphic PAM T2D-risk alleles reduce amidating enzyme activity, elevate circulating GLP-1 levels, and impair GLP-1 post-receptor signaling, culminating in a selective and clinically meaningful reduction in GLP-1RA efficacy

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