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Hypoglycemia risk in non-diabetics: This appears to remain low with retatrutide, but glucagon's role in glucose regulation warrants close monitoring

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Tirzepatide activates GIP and GLP-1 receptors, which slow gastric emptying

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Patients should understand: the importance of maintaining hydration despite reduced appetite, which symptoms warrant medical contact, how to use oral rehydration solutions if needed, and the value of keeping scheduled follow-up appointments

doi: 10.1016/j.cell.2019.08.031 56 SullivanJMBoreckiAAOleskevichS