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doi: 10.1155/2014/538737.538737 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Vittone F., Liberman A., Vasic D., et al

Most studies are small, short-term, or conducted in animals

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By comparison, Mounjaros pivotal SURMOUNT-1 trial reported up to around 22.5% mean weight loss at 72 weeks, and Wegovys STEP-1 trial reported around 14.9% at 68 weeks

As a result, it remains difficult to distinguish whether these effects represent direct modification of aging biology or improvements in underlying metabolic dysfunction

It is a first-in-class GLP-1/GIP receptor agonists that FDA approved on May 13, 2022, to improve blood sugar control in adults with T2DM as an adjunct to diet and exercise [15]