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Beyond weight reduction, combination therapy improves lipid profiles and blood pressure markersboth independent cardiovascular risk factors

Glucose-induced membrane depolarization entails opening of voltage-dependent Ca 2+ (VDC) channels, and the resulting Ca 2+ influx then triggers vesicular exocytosis and secretion of GLP-1 into the circulation (Figure 3) [266]

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The function may have important implications for age-related diseases in response to metabolic stress by promoting intracellular homeostasis, and MOTS-c gene polymorphisms have been found to be associated with human lifespan (18, 20)

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