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This delayed gastric emptying is therapeutic for weight loss and blood sugar management, but it also gives your gut bacteria more time to ferment undigested carbohydrates and proteinsproducing gas as a byproduct

And when you consider the long-term risks of obesitylike high blood pressure, cardiovascular disease, sleep apnea, and arthritisits easy to see why

Most gastrointestinal symptoms are mild to moderate and resolve as your body adjusts

The studys results provide insights into some known and previously unrecognized benefits and risks of GLP-1RA that may be useful to inform clinical care and guide research agendas. Al-Aly emphasized that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach

Monitoring parameters typically assessed in trials include: Body weight and BMI measured at each visit to track progress Blood glucose and HbA1c particularly important for participants with type 2 diabetes or non-diabetic hyperglycaemia (sometimes called prediabetes) Lipid profile including total cholesterol, LDL, HDL, and triglycerides Liver function tests given the metabolic effects of glucagon receptor activation Renal function especially relevant if gastrointestinal side effects lead to reduced fluid intake Blood pressure and heart rate cardiovascular parameters are routinely assessed Calcitonin levels some trial protocols include calcitonin measurement given the theoretical thyroid C-cell risk associated with GLP-1 receptor agonists, based on rodent data