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Seek immediate medical help (call 999 or go to A&E) if you experience: Severe allergic reactions , such as difficulty breathing, swelling of the face or throat, or widespread rash Severe, persistent abdominal pain , particularly if radiating to the back, which may indicate pancreatitis Severe dehydration with confusion, dizziness when standing, or inability to keep fluids down Contact your GP urgently or call NHS 111 if you experience: Persistent vomiting that prevents you from keeping down fluids for more than 24 hours Signs of dehydration , including reduced urination, dark urine, dry mouth, or dizziness Symptoms of gallbladder problems , including upper right abdominal pain, fever, or jaundice (yellowing of skin or eyes) Visual changes or eye pain, which may suggest diabetic retinopathy complications (particularly if you have pre-existing retinopathy and your blood glucose levels improve rapidly) [1] [6] Contact your GP or diabetes specialist nurse if: Gastrointestinal symptoms (nausea, vomiting, diarrhoea) persist beyond the first few weeks or worsen over time You experience recurrent hypoglycaemia (blood glucose below 4 mmol/L), especially if taking other diabetes medications You notice unexplained weight loss exceeding expected therapeutic effects Side effects significantly impact your quality of life or ability to continue treatment Regular monitoring is essential for patients on Mounjaro